琉球大学
発表論文
2023. 04.01 2023
  1. Shin M, Mori S, Mizoguchi T, Arai A, Kajiya H, Okamoto F, Bartlett JD, Matsushita M, Udagawa N, Okabe K. Mesenchymal cell TRPM7 expression is required for bone formation via the regulation of chondrogenesis. Bone. 2023 Jan;166:116579. doi: 10.1016/j.bone.2022.116579. Epub 2022 Oct 7. PMID: 36210025.
2022. 08.08 2022
  1. Takamatsu G, Manome Y, Lee JS, Toyama K, Hayakawa T, Hara-Miyauchi C, Hasegawa-Ogawa M, Katagiri C, Kondo T, James Okano H, Matsushita M. Generation of four iPSC lines from a family harboring a 1p36-35 haplotype linked with bipolar disorder and recurrent depressive disorder: Three-generation patients and a healthy sibling. Stem Cell Res. 2022 Sep 14;64:102915. doi: 10.1016/j.scr.2022.102915. Epub 2022 Sep 14. PMID: 36166871.
  2. Takamatsu G, Yanagi K, Koganebuchi K, Yoshida F, Lee JS, Toyama K, Hattori K, Katagiri C, Kondo T, Kunugi H, Kimura R, Kaname T, Matsushita M. Haplotype phasing of a bipolar disorder pedigree revealed rare multiple mutations of SPOCD1 gene in the 1p36-35 susceptibility locus. J Affect Disord. 2022 Aug 1;310:96-105. doi: 10.1016/j.jad.2022.04.150. Epub 2022 May 2. PMID: 35504398.
  3. Ashikari A, Miyazato M, Nakamura K, Yamashiro K, Nakamura T, Uema T, Uehara M, Masuzaki H, Saito S, Maeda S, Ishida H, Matsushita M. Obesity and Voiding Parameters in a Community-Based Population of Okinawa, Japan: Kumejima Digital Health Project (KDHP). Metabolites. 2022 May 23;12(5):468. doi: 10.3390/metabo12050468. PMID: 35629972; PMCID: PMC9145398.
  4. Nakachi S, Okamoto S, Tamaki K, Nomura I, Tomihama M, Nishi Y, Fukushima T, Tanaka Y, Morishima S, Imamura M, Maeda S, Tsutsui M, Matsushita M, Masuzaki H. Impact of anti-diabetic sodium-glucose cotransporter 2 inhibitors on tumor growth of intractable hematological malignancy in humans. Biomed Pharmacother. 2022 May;149:112864. doi: 10.1016/j.biopha.2022.112864. Epub 2022 Mar 31. PMID: 35367765.
  5. Nakashima Y, Miyagi-Shiohira C, Saitoh I, Watanabe M, Matsushita M, Tsukahara M, Noguchi H. Induced hepatic stem cells are suitable for human hepatocyte production. iScience. 2022 Sep 5;25(10):105052. doi: 10.1016/j.isci.2022.105052. PMID: 36147945.
  6. Noguchi H, Nakashima Y, Watanabe M, Matsushita M, Tsukahara M, Saitoh I, Miyagi-Shiohira C. Protocol for the generation of human induced hepatic stem cells using Sendai virus vectors. STAR Protoc. 2022 Dec 16;3(4):101884. doi: 10.1016/j.xpro.2022.101884. Epub 2022 Nov 23. PMID: 36595898.
  7. Uema T, Millman JF, Okamoto S, Nakamura T, Yamashiro K, Uehara M, Honma KI, Miyazato M, Ashikari A, Saito S, Maeda S, Imamura M, Ishida H, Matsushita M, Nakamura K, Masuzaki H. Profile of gut microbiota and serum metabolites associated with metabolic syndrome in a remote island most afflicted by obesity in Japan. Sci Rep. 2022 Oct 14;12(1):17292. doi: 10.1038/s41598-022-21708-0. PMID: 36241691.
2021. 08.08 2021
  1. Kaitsuka T, Matsushita M, Matsushita N. Regulation of Hypoxic Signaling and Oxidative Stress via the MicroRNA-SIRT2 Axis and Its Relationship with Aging-Related Diseases. Cells. 2021 Nov 26;10(12):3316. doi: 10.3390/cells10123316. PMID: 34943825; PMCID: PMC8699081.
  2. Kaitsuka T, Tomizawa K, Matsushita M. Heat Shock-Induced Dephosphorylation of Eukaryotic Elongation Factor 1BδL by Protein Phosphatase 1. Front Mol Biosci. 2021 Jan 14;7:598578. doi: 10.3389/fmolb.2020.598578. PMID: 33521052; PMCID: PMC7841112.
  3. Nadolni W, Immler R, Hoelting K, Fraticelli M, Ripphahn M, Rothmiller S, Matsushita M, Boekhoff I, Gudermann T, Sperandio M, Zierler S. TRPM7 Kinase Is Essential for Neutrophil Recruitment and Function via Regulation of Akt/mTOR Signaling. Front Immunol. 2021 Feb 15;11:606893. doi: 10.3389/fimmu.2020.606893. PMID: 33658993; PMCID: PMC7917126.
  4. Beesetty P, Rockwood J, Kaitsuka T, Zhelay T, Hourani S, Matsushita M, Kozak JA. Phagocytic activity of splenic macrophages is enhanced and accompanied by cytosolic alkalinization in TRPM7 kinase-dead mice. FEBS J. 2021 Jun;288(11):3585-3601. doi: 10.1111/febs.15683. Epub 2021 Jan 6. PMID: 33354894; PMCID: PMC8184566.
  5. Miyazato M, Ashikari A, Nakamura K, Nakamura T, Yamashiro K, Uema T, Uehara M, Masuzaki H, Saito S, Maeda S, Ishida H, Matsushita M. Effect of a mobile digital intervention to enhance physical activity in individuals with metabolic disorders on voiding patterns measured by 24-h voided volume monitoring system: Kumejima Digital Health Project (KDHP). Int Urol Nephrol. 2021 Aug;53(8):1497-1505. doi: 10.1007/s11255-021-02867-x. Epub 2021 Apr 28. PMID: 33909235; PMCID: PMC8280019.
2020. 08.08 2020
  1. Kaitsuka T, Matsushita M, Matsushita N. SIRT2 inhibition activates hypoxia-inducible factor 1α signaling and mediates neuronal survival. Biochem Biophys Res Commun. 2020 Sep 3;529(4):957-962. doi: 10.1016/j.bbrc.2020.06.159. Epub 2020 Jul 30. PMID: 32819605.
  2. Millman J, Okamoto S, Kimura A, Uema T, Higa M, Yonamine M, Namba T, Ogata E, Yamazaki S, Shimabukuro M, Tsutsui M, Matsushita M, Ikematsu S, Masuzaki H. Metabolically and immunologically beneficial impact of extra virgin olive and flaxseed oils on composition of gut microbiota in mice. Eur J Nutr. 2020 Sep;59(6):2411-2425. doi: 10.1007/s00394-019-02088-0. Epub 2019 Sep 10. PMID: 31506767; PMCID: PMC7413911.
2019. 02.27 2019
  1. Mittermeier L, Demirkhanyan L, Stadlbauer B, Breit A, Recordati C, Hilgendorff A, Matsushita M, Braun A, Simmons DG, Zakharian E,Gudermann T, Chubanov V. TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival.
    Proc Natl Acad Sci U S A. 2019 Feb 15. pii: 201810633. doi: 10.1073/pnas.1810633116.
  2. Miyazato M, Yonemoto K, Ashikari A, Saito S, Yamashiro K, Uehara M, Masuzaki H, Ishida H, Matsushita M. Validation of a novel digital health monitoring system to measure the volume of voided urine. Neurourol Urodyn. 2019 Apr;38(4):1106-1110. doi: 10.1002/nau.23965. Epub 2019 Mar 8. PMID: 30848839.
  3. Nishi Y, Murakami A, Murayama Y, Tsukahara N, Okamoto S, Nakachi S, Morichika K, Tamaki K, Noguchi H, Matsushita M, Karube KN, Fukushima T, Morishima S, Kishimoto H, Masuzaki H. Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models. Transpl Immunol. 2019 Aug;55:101205. doi: 10.1016/j.trim.2019.03.004. Epub 2019 Apr 1. PMID: 30946889.
2018. 02.15 2018
  1. Beesetty P, Wieczerzak KB, Gibson J, Kaitsuka T, Luu CT, Matsushita M & Kozak JA. Inactivation of TRPM7 kinase in mice results in enlarged spleens, reduced T-cell proliferation and diminished store-operated calcium entry.
    Scientific Reports 2018 in press
  2. Gotru SK, Chen W, Kraft P, Becker IC, Wolf K, Stritt S, Zierler S, Hermanns HM, Rao D, Perraud AL, Schmitz C, Zahedi RP, Noy PJ, Tomlinson MG, Dandekar T, Matsushita M, Chubanov V, Gudermann T, Stoll G, Nieswandt B, Braun A. TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice (2018)
    Arterioscler Thromb Vasc Biol 38(2):344-352. doi: 10.1161/ATVBAHA.117.310391.
  3. Hatayama N, Hirai S, Naito M, Terayama H, Araki J, Yokota H, Matsushita M, Li XK, Itoh M. Preservation of rat limbs by hyperbaric carbon monoxide and oxygen.
    Scientific Reports. 2018 Apr 26;8(1):6627. doi: 10.1038/s41598-018-25070-y.
  4. Kaitsuka T, Kiyonari H, Shiraishi A, Tomizawa K, Matsushita M. Deletion of Long Isoform of Eukaryotic Elongation Factor 1Bδ Leads to Audiogenic Seizures and Aversive Stimulus-Induced Long-Lasting Activity Suppression in Mice.
    Front Mol Neurosci.2018 Oct 2;11:358. doi: 10.3389/fnmol. 2018.00358. eCollection 2018.
  5. Zhelay T, Wieczerzak KB, Beesetty P, Alter GM, Matsushita M, Kozak JA. Depletion of plasma membrane-associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg2+, spermine, and pH.
    J Biol Chem. 2018 Nov 23;293(47):18151-18167. doi: 10.1074/jbc.RA118.004066. Epub 2018 Oct 10. PMID: 30305398
2017. 02.14 2017
  1. Takamatsu G, Katagiri C, Tsumuraya T, Shimizu-Okabe C, Nakamura W, Nakamura-Higa M, Hayakawa T, Wakabayashi S, Kondo T, Takayama C, Matsushita M (2017) Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons.
    Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2016.12.036.
  2. Romagnani A, Vettore V, Rezzonico-Jost T, Hampe S, Rottoli E, Nadolni W, Perotti M, Meier MA, Hermanns C, Geiger S, Wennemuth G, Recordati C, Matsushita M, Muehlich S, Proietti M, Chubanov V, Gudermann T, Grassi F, Ziegler S (2017)
    TRPM7 kinase activity is essential for T cell colonization and alloreactivity in the gut.
    Nature Communications 8. doi: 10.1038/s41467-017-01960-z.
  3. Ogata K, Tsumuraya T, Oka K, Shin M, Okamoto F, Kajiya H, Katagiri C, Ozaki M, Matsushita M, Okabe K. The crucial role of the TRPM7 kinase domain in the early stage of amelogenesis. (2017)
    Scientific Reports 7 :18099. doi: 10.1038/s41598-017-18291-0. PMID: 29273814
  4. Kobayashi M, Shimizu-Okabe C, Kim J, Kobayashi S, Matsushita M, Masuzaki H, Takayama C. Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior (2017).
    Neurosci Res. pii: S0168-0102(17)30313-9. doi: 10.1016/j.neures.2017.11.007.
  5. Kozuka C, Kaname T, Shimizu-Okabe C, Takayama C, Tsutsui M, Matsushita M, Abe K, Masuzaki H. Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice(2017)
    Diabetologia 60(8):1502-1511. doi: 10.1007/s00125-017-4305-4.
  6. Kina-Tanada M, Sakanashi M, Tanimoto A, Kaname T, Matsuzaki T, Noguchi K, Uchida T, Nakasone J, Kozuka C, Ishida M, Kubota H, Taira Y, Totsuka Y, Kina SI, Sunakawa H, Omura J, Satoh K, Shimokawa H, Yanagihara N, Maeda S, Ohya Y, Matsushita M, Masuzaki H, Arasaki A, Tsutsui M. Long-term dietary nitrite and nitrate deficiency causes the metabolic syndrome, endothelial dysfunction and cardiovascular death in mice (2017)
    Diabetologia 60(6):1138-1151. doi: 10.1007/s00125-017-4259-6.
  7. Sunagawa M, Shimizu-Okabe C, Kim J, Kobayashi S, Kosaka Y, Yanagawa Y, Matsushita M, Okabe A, Takayama C. Distinct development of the glycinergic terminals in the ventral and dorsal horns of the mouse cervical spinal cord (2017)
    Neuroscience 20;343:459-471. doi: 10.1016/j.neuroscience.2016.12.032.
2016. 08.03 2016
  1. Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru SK, van Eeuwijk JM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A.
    Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture (2016)
    Nature Communications. doi: 10.1038/ncomms11097.
  2. Matsushita N, Suzuki M , Ikebe E , Nagashima S, Inatome R , Asano K, Tanaka M, Matsushita M, Kondo E, Iha H, Yanagi S (2016) Regulation of B cell differentiation by the ubiquitin-binding protein TAX1BP1.
    Scientific Reports 6:31266. doi: 10.1038/srep31266.
  3. Terayama H, Hirai S, Naito M, Qu N, Katagiri C, Nagahori K, Hayashi S, Sasaki H, Moriya S, Hiramoto M, Miyazawa K, Hatayama N, Li ZL, Sakabe K, Matsushita M, Itoh M (2016) Specific autoantigens identified by sera obtained from mice that are immunized with testicular germ cells alone.
    Scientific Reports. 6:35599. doi: 10.1038/srep35599.
2015. 01.09 2015
  1. Higa M, Katagiri C, Shimizu-Okabe C, Tsumuraya T, Sunagawa M, Nakamura M, Ishiuchi S, Takayama C, Kondo E, Matsushita M (2015) Identification of a novel cell-penetrating peptide targeting human glioblastoma cell lines as a cancer-homing transporter.
    Biochem Biophys Res Commun. doi: 10.1016/j.bbrc.2014.12.089
  2. Kozuka C, Sunagawa S, Ueda R, Higa M, Tanaka H, Shimizu-Okabe C, Ishiuchi S, Takayama C, Matsushita M, Tsutsui M, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H (2015)
    Gamma-oryzanol protects pancreatic β-cells against endoplasmic reticulum stress in male mice. Endocrinology. 156, 1242-1250
  3. Fukuda T, Kakinohana M, Takayama C, Matsushita M, Sugahara K (2015) Dietary supplementation with sodium nitrite can exert neuroprotective effects on global cerebral ischemia/reperfusion in mice.
    J Anesth. 29, 609-617.
  4. Kaitsuka T and Matsushita M. Regulation of Translation Factor EEF1D Gene Function by Alternative Splicing (2015)
    Int. J. Mol. Sci. 16, 3970-3979.
  5. Kozuka C, Sunagawa S, Ueda R, Higa M, Ohshiro Y, Tanaka H, Shimizu-Okabe C, Takayama C, Matsushita M, Tsutsui M, Ishiuchi S, Nakata M, Yada T, Miyazaki JI, Oyadomari S, Shimabukuro M, Masuzaki H.
    A novel insulinotropic mechanism of whole grain-derived γ-oryzanol via the suppression of local dopamine D2 receptor signalling in mouse islet (2015)
    Br J Pharmacol. doi: 10.1111/bph.13236.
  6. Miyagi-Shiohira C, Kurima K, Kobayashi N, Saitoh I, Watanabe M, Noguchi Y, Matsushita M, Noguchi H. Cryopreservation of Adipose-Derived Mesenchymal Stem Cells (2015)
    Cell Med. 8, 3-7. doi: 10.3727/215517915X689100.
  7. Noguchi H, Miyagi-Shiohira C, Kurima K, Kobayashi N, Saitoh I, Watanabe M, Noguchi Y, Matsushita M. Islet Culture/Preservation Before Islet Transplantation (2015)
    Cell Med. 8, 25-9. doi: 10.3727/215517915X689047.
2014. 06.24 2014
  1. Kaitsuka T, Katagiri C, Beesetty P, Nakamura K, Hourani S, Tomizawa K, Ashot JK and Matsushita M (2014)
    Inactivation of TRPM7 kinase activity does not impair its channel function in mice
    Scientific Reports 4; 5718.
  2. Uchida T, Furuno Y, Tanimoto A, Toyohira Y, Arakaki K, Kina-Tanada M, Kubota H, Sakanashi M, Matsuzaki T, Noguchi K, Nakasone J, Igarashi T, Ueno S, Matsushita M, Ishiuchi S, Masuzaki H, Ohya Y, Yanagihara N, Shimokawa H, Otsuji Y, Tamura M, Tsutsui M (2014)
    Development of an experimentally useful model of acute myocardial infarction: 2/3 nephrectomized triple nitric oxide synthases-deficient mouse.
    J Mol Cell Cardiol 77C:29-41.
  3. Li ST, Wang Y, Matsushita M. Neurological disorders related neuronal network impairment: function and mechanism (2014)
    Neural Plasticity. 945078. doi: 10.1155/2014/945078.
2013. 03.13 2013
  1. Ogawa K, Kohshi K, Ishiuchi S, Matsushita M, Yoshimi N, Murayama S (2013)
    Old but new methods in radiation oncology: hyperbaric oxygen therapy.
    Int J Clin Oncol 18: 364-370.
  2. Tsumuraya T, Matsushita M (2013)
    COPA and SLC4A4 are required for cellular entry of arginine-rich peptides.
    PLoS ONE 9: e86639.
2012. 01.26 2012
  1. Naito M, Hirai S, Mihara M, Terayama H, Hatayama N, Hayashi S, Matsushita M, Itoh M (2012)
    Effect of a magnetic field on Drosophila under supercooled conditions.
    PLoS ONE 7:e51902.
  2. Iketani M, Iizuka A, Sengoku K, Kurihara Y, Nakamura F, Sasaki Y, Sato Y, Yamane M, Matsushita M, Nairn AC, Takamatsu K, Goshima Y, Takei K (2012)
    Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones.
    Developmental Neurobiology 73: 230-246
  3. Kozuka C, Yabiku K, Sunagawa S, Ueda R, Taira S, Ohshiro H, Ikema T, Yamakawa K, Higa M, Tanaka H, Takayama C, Matsushita M, Oyadomari S, Shimabukuro M, Masuzaki H (2012)
    Brown rice and its component, γ-oryzanol, attenuate the preference for high-fat diet by decreasing hypothalamic endoplasmic reticulum stress in mice.
    Diabetes doi: 10.2337/db11-1767 .
  4. Kondo E, Saito K, Tashiro Y, Kamide K, Uno S, Furuya T, Mashita M, Nakajima K, Tsumuraya T, Kobayashi N, Nishibori M, Tanimoto M, Matsushita M (2012)
    Tumour lineage-homing cell-penetrating peptides as anticancer molecular delivery systems.
    Nature Communications 3 : 951 doi: 10.1038/ncomms1952.
  5. Chokshi R, Matsushita M, Kozak JA (2012) Detailed examination of Mg2+ and pH sensitivity of human TRPM7 channels. American Journal of Physiology-Cell Physiology 302:1004-1011.
  6. Chokshi R, Matsushita M, Kozak JA (2012) Sensitivity of TRPM7 channels to Mg2+ characterized in cell-free patches of Jurkat T lymphocytes. American Journal of Physiology-Cell Physiology 302: 1642-1651.


2011. 03.22 2011
  1. Renault-Mihara F, Katoh H, Ikegami T, Iwanami A, Mukaino M, Yasuda A, Nori S, Mabuchi Y, Tada H, Shibata S, Saito K, Matsushita M, Kaibuchi K, Okada S, Toyama Y, Nakamura M, Okano H (2011) Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition.
    EMBO Molecular Medicine 3:682-696.
  2. Kaitsuka T, Sheng-Tian L, Nakamura K, Takao K, Miyakawa T, Matsushita M (2011)
    Forebrain-specific constitutively active CaMKKalfa transgenic mice show deficits in  hippocampus-dependent long-term memory.
    Neurobiology of Learning and Memory 96: 238-247.
  3. Kaitsuka T, Tomizawa K, Matsushita M (2011)
    Transformation of eEF1Bdelta into heat shock response transcription factor by alternative splicing.
    EMBO reports 12: 673-681.
  4. Saito K, Kondo E, Matsushita M (2011)
    MicroRNA 130 Family Regulates the Hypoxia Response Signal through the P-body Protein DDX6.
    Nucleic Acids Research 39: 6086-6099.
2010. 06.13 2010
  1. Saito K, Adachi N, Koyama H,Matsushita M (2010)
    OGFOD1, a member of the 2-Oxoglutarate and Iron Dependent Dioxygenase Family, Functions in Ischemic Signaling.
    FEBS Letters 584. 3340-3347.
  2. Noguchi H, Matsushita M, Kobayashi N, Levy MF, Matsumoto S (2010)
    Rent Advances in Protein Transduction Technology.
    Cell Transplant 19: 649-654.
  3. Tateishi A, Matsushita M, Asai T, Masuda Z, Kuriyama M, Kanki K, Ishino K, Kawada M, Sano S, Matsui H (2010) Effect of inhibition of glycogen synthetase kinase-3 on cariac hypertrophy during acute pressure overload.
    Gen Thorac Cardiovasc Surg 58: 265-270.
2009. 09.30 2009
  1. Sunagawa M, Shimada S, Nakamura M, Kosugi T (2009)
    RNAi targeting embryonic myosin heavy chain isoform inhibited bound thrombin-induced migration of vascular smooth muscle cells.
    J Vasc Res 46: 55-63.
2009. 09.30 2008
  1. Han XJ, Lu YF, Li SA, Kaitsuka T, Sato Y, Tomizawa K, Nairn AC, Takei K, Matsui H, Matsushita M (2008) CaM kinase Ia-induced phosphorylation of Drp1 regulates mitochondrial morphology.
    J Cell Biol 182:573-85.
  2. Ono R, Matsuoka J, Yamatsuji T, Naomoto Y, Tanaka N, Matsui H, Matsushita M (2008)
    M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.
    Int J Mol Med 22:199-203.
  3. Han XJ, Lu YF, Li SA, Tomizawa K, Takei K, Matsushita M, Matsui H (2008) Involvement of calcineurin in glutamate-induced mitochondrial dynamics in neurons.
    Neurosci Res 60: 114-119.
2009. 09.30 2007
  1. Tezuka H, Abe Y, Iwata M, Takeuchi H, Ishikawa H, Matsushita M, Shiohara T, Akira S, Ohteki T (2007) Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells.
    Nature 448: 929-933.
  2. Morita Y, Ujike H, Tanaka Y, Otani K, Kishimoto M, Morio A, Kotaka T, Okahisa Y, Matsushita M, Morikawa A, Hamase K, Zaitsu K, Kuroda S (2007) A GeneticVariant of the Serine Racemase Gene Is Associated with Schizophrenia.
    Biol Psychiatry
    61: 1200-1203.
  3. Iizuka A, Sengoku K, Iketani M, Nakamura F, Sato Y, Matsushita M, Nairn AC, Takamatsu K, Goshima Y, Takei K (2007) Calcium-induced synergistic inhibition of a translational factor eEF2 in nerve growth cones.
    Biochem Biophys Res Commun 353 : 244-250.
  4. Ohta S, Hanashiro K, Sunagawa M, Tono T, Suzuki M, Kosugi T (2007) Involvement of Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP)-1 in the Potentiation of Ce mRNA expression in human tonsil-derived cells.
    Eur Arch Otorthinolaryngol 264: 245-250.
  5. Shimada S, Sunagawa M, Hanashiro K, Nakamura M, Kosugi T (2007) RNA interference targeting embryonic myosin heavy chain isoform inhibited mRNA expressions of phenotype markers in rabbit cultured vascular smooth muscle cells.
    Heart Vessels 22: 41-47.
  6. Hanashiro K, Sunagawa M, Nakasone T, Nakamura M, Kosugi T (2007) Inhibition of IgE-mediated phosphorylation of FceRIg protein by antiallergic drugs in rat basophilic leukemia (RBL-2H3) cells: A novel action of antiallergic drugs.
    Int Immunopharmacol 7: 994-1002.
  7. Sunagawa M, Nakamura M, Kosugi T (2007) Cloning of habutobin cDNA and antithrombotic activity of recombinant protein.
    Biochem Biophys Res Commun 362: 899-904.
2009. 09.30 2006
  1. Kuriyama M, Matsushita M, Tateishi A, Moriwaki A, Tomizawa K, Ishino K, Sano S, Matsui H (2006) A cell-permeable NFAT inhibitor peptide prevents pressure-overload cardiac hypertrophy.
    Chem Biol Drug Des 67:238-243.
  2. Noguchi H, Matsumoto S, Okitsu T, Iwanaga Y, Yonekawa Y, Nagata H, Matsushita M, Wei FY, Matsui H, Minami K, Seino S, Masui Y, Futaki S, Tanaka K (2006) PDX-1 protein is internalized by lipid raft-dependent macropinocytosis.
    Cell Transplant 14:637-645.
  3. Inoue M, Tomizawa K, Matsushita M, Lu YF, Yokoyama T, Yanai H, Takashima A, Kumon H, Matsui H (2006) p53 protein transduction therapy: successful targeting and inhibition of the growth of the bladder cancer cells.
    Eur Urol 49:161-168.
  4. Hanashiro K, Sunagawa M, Tokeshi Y, Nakasone T, Ohta S, Nakamura M, Kosugi T (2006) Antiallergic drugs, azelastine hydrochloride and epinastine hydrochloride, inhibit ongoing IgE secretion of rat IgE-producing hybridoma FE-3 cells.
    Eur J Pharmacol 547: 174-183.
  5. Sunagawa M, Shimada S, Hanashiro K, Nakamura M, Kosugi T (2006) Elevation of intracellular cAMP up-regulated thrombomodulin mRNA in cultured vascular endothelial cells derived from spontaneous type-II diabetes mellitus model rat.
    Endothelium 13: 325-333.
  6. Sunagawa M, Shingaki Y, Oonishi A, Nakamura M, Kosugi T (2006) Concomitant oral ingestion of germanium-132 and curcumin increased mortality rate by aggravating hepatic dysfunction in Long-Evans Cinnamon rats.
    J Health Sci 52: 684-693.
  7. Hanashiro K, Ohta S, Sunagawa M, Nakamura M, Suzuki M, Kosugi T (2006) Modification of Ce mRNA expression by EBV-encoded latent membrane protein1.
    Mediat Inflamm 1-7.
2009. 09.30 2005
  1. Kozak JA, Matsushita M, Nairn AC, and Cahalan MD (2005) Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition and rundown of TRPM7/MIC channels.
    J Gen Physiol 126: 499-514.
  2. Wei FY, Nagashima K, Ohshima T, Saheki Y, Lu YF, Matsushita M, Yamada Y, Mikoshiba K, Seino Y, Matsui H, Tomizawa K (2005) Cdk5-dependent regulation of glucose-stimulated insulin secretion.
    Nature Medicine
    10: 1104-1108.
  3. Noguchi H, Bonner-Weir S, Wei FY, Matsushita M, Matsumoto S (2005) BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence.
    Diabetes 54: 2859-2866 (2005).
  4. Saheki Y, Li ST, Matsushita M, Wu YM, Cai WH, Wei FY, Lu YF, Moriwaki A, Tomizawa K, Matsui H (2005) A new approach to inhibiting astrocytic IP(3)-induced intracellular calcium increase in an astrocyte-neuron co-culture system.
    Brain Res 1055: 196-201.
  5. Michiue H, Tomizawa K, Matsushita M, Tamiya T, Lu YF, Ichikawa T, Date I, Matsui H (2005) Ubiquitination-resistant p53 protein transduction therapy facilitates anti-cancer effect on the growth of human malignant glioma cells.
    FEBS Letters 579:3965-3969.
  6. Noguchi H, Matsushita M, Matsumoto S, Lu YF, Matsui H, Bonner-Weir S (2005) Mechanism of PDX-1 protein transduction.
    Biochem Biophys Res Commun 332:68-74.
  7. Wu HY, Yuen EY, Lu YF, Matsushita M, Matsui H, Yan Z, Tomizawa K (2005) Regulation of NMDA receptors by calpain in cortical neurons.
    J Biol Chem 280:21588-21593.
  8. Matsushita M, Kozak JA, Shimizu Y, McLachlin D, Yamaguchi H, Wei FY, Tomizawa K, Matsui H, Chait B, Cahalan MD and Nairn AC (2005) Channel function dissociated from kinase activity and autophosphorylation in TRPM7/ChaK1.
    J Biol Chem 280:20793-20803.
  9. Arataki S, Tomizawa K, Moriwaki A, Nishida K, Matsushita M, Ozaki T, Kunisada T, Yoshida A, Inoue H, Matsui H (2005) Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats.
    J Neurotrauma 22:398-406.
  10. Michiue H, Tomizawa K, Wei FY, Matsushita M, Lu YF, Ichikawa T, Tamiya T, Date I, Matsui H (2005) The NH2-terminal of influenza virus hemagglutinin-2 subunit peptides enhance the anti-tumor potency of poly-arginine-mediated p53 protein transduction.
    J Biol Chem
    280:8285-8289.
  11. Kumashiro S, Lu YF, Tomizawa K, Matsushita M, Wei FY, Matsui H (2005) Regulation of synaptic vesicle recycling by calcineurin in different vesicle pools.
    Nerosci Res 51:435-443.
  12. Matsushita M and Matsui H (2005) Protein Transduction Technology.
    J Mol Med 83, 24-28.
  13. Sunagawa M, Yamakawa M, Shimabukuro M, Higa N, Takasu N, Kosugi T (2005) Electrophysiologic characteristics of atrial myocytes in levo-thyroxine-treated rats.
    Thyroid 15:3-11.
  14. Yamakawa M, Sunagawa M, Shimabukuro M, Higa N, Takasu N, Kosugi T (2005) Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rats.
    Thyroid 15:653-659.
2009. 09.30 2004
  1. #Matsushita M, #Noguchi H, Lu YF, Tomizawa K, Michiue H, Li ST, Hirose K, Bonner-Weir S, Matsui H (2004) Photo-acceleration of protein release from endosome in the protein transduction system.
    FEBS Letters 572, 221-226. #equaly contributed
  2. Li ST, Matsushita M, Moriwaki A, Saheki Y, Lu YF, Tomizawa K, Wu HY, Terada H, Matsui H (2004) Human Immunodeficiency Virus Type 1 Tat Potentiates Extrasynaptic N-methyl-D-Aspartate Receptor-Mediated Calcium Influx and Attenuates Spatial Learning.
    Annals Neurology 55: 362-371.
  3. Noguchi H, Matsushita M, Okitsu T, Moriwaki A, Tomizawa K, Kang S, Li ST, Kobayashi N, Tanaka K, Tanaka N, Matsui H (2004) A novel cell-permeable peptide allows successful allogeneic islet transplantation in mice.
    Nature Medicine 10: 305-309.
  4. Wu HY, Tomizawa K, Oda Y, Wei FY, Lu YF, Matsushita M, Li ST, Moriwaki A, Matsui H (2004) Critical role of calpain-mediated cleavage of calcineurinin excitotoxic neurodegeneration.
    J Biol Chem 279: 4929-4940.
  5. Sunagawa M, Shimada S, Zhang Z, Oonishi A, Nakamura M, Kosugi T (2004) Plasma insulin concentration was increased by long-term ingestion of guava juice in spontaneous non-insulin-dependent diabetes mellitus (NIDDM) rats.
    J Health Sci 50: 674-678.

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