琉球大学医学部生理学第一分野

Chokshi R, Matsushita M, Kozak JA.
Detailed examination of Mg²⁺ and pH sensitivity of human TRPM7 channels.
American Journal of Physiology-Cell Physiology in press

Chokshi R, Matsushita M, Kozak JA.
Sensitivity of TRPM7 channels to Mg²⁺ characterized in cell-free patches of Jurkat T lymphocytes.
American Journal of Physiology-Cell Physiology in press

Renault-Mihara F, Katoh H, Ikegami T, Iwanami A, Mukaino M, Yasuda A, Nori S, Mabuchi Y, Tada H, Shibata S, Saito K, Matsushita M, Kaibuchi K, Okada S, Toyama Y, Nakamura M, Okano H (2011).Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition.
EMBO Molecular Medicine 3:682-696.

Kaitsuka T, Sheng-Tian L, Nakamura K, Takao K, Miyakawa T, Matsushita M (2011)
Forebrain-specific constitutively active CaMKKalfa transgenic mice show deficits in  hippocampus-dependent long-term memory.
Neurobiology of Learning and Memory 96: 238-247.

Kaitsuka T, Tomizawa K, Matsushita M (2011)
Transformation of eEF1Bdelta into heat shock response transcription factor by alternative splicing.
EMBO reports 12: 673-681.

Saito K, Kondo E, Matsushita M (2011)
MicroRNA 130 Family Regulates the Hypoxia Response Signal through the P-body Protein DDX6.
Nucleic Acids Research 39: 6086-6099.

Saito K, Adachi N, Koyama H,Matsushita M (2010)
OGFOD1, a member of the 2-Oxoglutarate and Iron Dependent Dioxygenase Family, Functions in Ischemic Signaling.
FEBS Letters 584. 3340-3347.

Noguchi H, Matsushita M, Kobayashi N, Levy MF, Matsumoto S (2010)
Rent Advances in Protein Transduction Technology.
Cell Transplant. PMID:20525440

Tateishi A, Matsushita M, Asai T, Masuda Z, Kuriyama M, Kanki K, Ishino K, Kawada M, Sano S, Matsui H (2010) Effect of inhibition of glycogen synthetase kinase-3 on cariac hypertrophy during acute pressure overload.
Gen Thorac Cardiovasc Surg 58: 265-270.

Sunagawa M, Shimada S, Nakamura M, Kosugi T (2009)
RNAi targeting embryonic myosin heavy chain isoform inhibited bound thrombin-induced migration of vascular smooth muscle cells.
J Vasc Res 46: 55-63.

Han XJ, Lu YF, Li SA, Kaitsuka T, Sato Y, Tomizawa K, Nairn AC, Takei K, Matsui H, Matsushita M (2008) CaM kinase Ia-induced phosphorylation of Drp1 regulates mitochondrial morphology.
J Cell Biol 182:573-85.

Ono R, Matsuoka J, Yamatsuji T, Naomoto Y, Tanaka N, Matsui H, Matsushita M (2008)
M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.
Int J Mol Med 22:199-203.

Han XJ, Lu YF, Li SA, Tomizawa K, Takei K, Matsushita M, Matsui H (2008) Involvement of calcineurin in glutamate-induced mitochondrial dynamics in neurons.
Neurosci Res 60: 114-119.

Tezuka H, Abe Y, Iwata M, Takeuchi H, Ishikawa H, Matsushita M, Shiohara T, Akira S, Ohteki T (2007) Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells.
Nature 448: 929-933.

Morita Y, Ujike H, Tanaka Y, Otani K, Kishimoto M, Morio A, Kotaka T, Okahisa Y, Matsushita M, Morikawa A, Hamase K, Zaitsu K, Kuroda S (2007) A GeneticVariant of the Serine Racemase Gene Is Associated with Schizophrenia.
Biol Psychiatry 61: 1200-1203.

Iizuka A, Sengoku K, Iketani M, Nakamura F, Sato Y, Matsushita M, Nairn AC, Takamatsu K, Goshima Y, Takei K (2007) Calcium-induced synergistic inhibition of a translational factor eEF2 in nerve growth cones.
Biochem Biophys Res Commun 353 : 244-250.

Ohta S, Hanashiro K, Sunagawa M, Tono T, Suzuki M, Kosugi T (2007) Involvement of Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP)-1 in the Potentiation of Ce mRNA expression in human tonsil-derived cells.
Eur Arch Otorthinolaryngol 264: 245-250.

Shimada S, Sunagawa M, Hanashiro K, Nakamura M, Kosugi T (2007) RNA interference targeting embryonic myosin heavy chain isoform inhibited mRNA expressions of phenotype markers in rabbit cultured vascular smooth muscle cells.
Heart Vessels 22: 41-47.

Hanashiro K, Sunagawa M, Nakasone T, Nakamura M, Kosugi T (2007) Inhibition of IgE-mediated phosphorylation of FceRIg protein by antiallergic drugs in rat basophilic leukemia (RBL-2H3) cells: A novel action of antiallergic drugs.
Int Immunopharmacol 7: 994-1002.

Sunagawa M, Nakamura M, Kosugi T (2007) Cloning of habutobin cDNA and antithrombotic activity of recombinant protein.
Biochem Biophys Res Commun 362: 899-904.

Kuriyama M, Matsushita M, Tateishi A, Moriwaki A, Tomizawa K, Ishino K, Sano S, Matsui H (2006) A cell-permeable NFAT inhibitor peptide prevents pressure-overload cardiac hypertrophy.
Chem Biol Drug Des 67:238-243.

Noguchi H, Matsumoto S, Okitsu T, Iwanaga Y, Yonekawa Y, Nagata H, Matsushita M, Wei FY, Matsui H, Minami K, Seino S, Masui Y, Futaki S, Tanaka K (2006) PDX-1 protein is internalized by lipid raft-dependent macropinocytosis.
Cell Transplant 14:637-645.

Inoue M, Tomizawa K, Matsushita M, Lu YF, Yokoyama T, Yanai H, Takashima A, Kumon H, Matsui H (2006) p53 protein transduction therapy: successful targeting and inhibition of the growth of the bladder cancer cells.
Eur Urol 49:161-168.

Hanashiro K, Sunagawa M, Tokeshi Y, Nakasone T, Ohta S, Nakamura M, Kosugi T (2006) Antiallergic drugs, azelastine hydrochloride and epinastine hydrochloride, inhibit ongoing IgE secretion of rat IgE-producing hybridoma FE-3 cells.
Eur J Pharmacol 547: 174-183.

Sunagawa M, Shimada S, Hanashiro K, Nakamura M, Kosugi T (2006) Elevation of intracellular cAMP up-regulated thrombomodulin mRNA in cultured vascular endothelial cells derived from spontaneous type-II diabetes mellitus model rat.
Endothelium 13: 325-333.

Sunagawa M, Shingaki Y, Oonishi A, Nakamura M, Kosugi T (2006) Concomitant oral ingestion of germanium-132 and curcumin increased mortality rate by aggravating hepatic dysfunction in Long-Evans Cinnamon rats.
J Health Sci 52: 684-693.

Hanashiro K, Ohta S, Sunagawa M, Nakamura M, Suzuki M, Kosugi T (2006) Modification of Ce mRNA expression by EBV-encoded latent membrane protein1.
Mediat Inflamm 1-7.

Kozak JA, Matsushita M, Nairn AC, and Cahalan MD (2005) Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition and rundown of TRPM7/MIC channels.
J Gen Physiol 126: 499-514.

Wei FY, Nagashima K, Ohshima T, Saheki Y, Lu YF, Matsushita M, Yamada Y, Mikoshiba K, Seino Y, Matsui H, Tomizawa K (2005) Cdk5-dependent regulation of glucose-stimulated insulin secretion.
Nature Medicine 10: 1104-1108.

Noguchi H, Bonner-Weir S, Wei FY, Matsushita M, Matsumoto S (2005) BETA2/NeuroD protein can be transduced into cells due to an arginine- and lysine-rich sequence.
Diabetes 54: 2859-2866 (2005).

Saheki Y, Li ST, Matsushita M, Wu YM, Cai WH, Wei FY, Lu YF, Moriwaki A, Tomizawa K, Matsui H (2005) A new approach to inhibiting astrocytic IP(3)-induced intracellular calcium increase in an astrocyte-neuron co-culture system.
Brain Res 1055: 196-201.

Michiue H, Tomizawa K, Matsushita M, Tamiya T, Lu YF, Ichikawa T, Date I, Matsui H (2005) Ubiquitination-resistant p53 protein transduction therapy facilitates anti-cancer effect on the growth of human malignant glioma cells.
FEBS Letters 579:3965-3969.

Noguchi H, Matsushita M, Matsumoto S, Lu YF, Matsui H, Bonner-Weir S (2005) Mechanism of PDX-1 protein transduction.
Biochem Biophys Res Commun 332:68-74.

Wu HY, Yuen EY, Lu YF, Matsushita M, Matsui H, Yan Z, Tomizawa K (2005) Regulation of NMDA receptors by calpain in cortical neurons.
J Biol Chem 280:21588-21593.

Matsushita M, Kozak JA, Shimizu Y, McLachlin D, Yamaguchi H, Wei FY, Tomizawa K, Matsui H, Chait B, Cahalan MD and Nairn AC (2005) Channel function dissociated from kinase activity and autophosphorylation in TRPM7/ChaK1.
J Biol Chem 280:20793-20803.

Arataki S, Tomizawa K, Moriwaki A, Nishida K, Matsushita M, Ozaki T, Kunisada T, Yoshida A, Inoue H, Matsui H (2005) Calpain inhibitors prevent neuronal cell death and ameliorate motor disturbances after compression-induced spinal cord injury in rats.
J Neurotrauma 22:398-406.

Michiue H, Tomizawa K, Wei FY, Matsushita M, Lu YF, Ichikawa T, Tamiya T, Date I, Matsui H (2005) The NH2-terminal of influenza virus hemagglutinin-2 subunit peptides enhance the anti-tumor potency of poly-arginine-mediated p53 protein transduction.
J Biol Chem 280:8285-8289.

Kumashiro S, Lu YF, Tomizawa K, Matsushita M, Wei FY, Matsui H (2005) Regulation of synaptic vesicle recycling by calcineurin in different vesicle pools.
Nerosci Res 51:435-443.

Matsushita M and Matsui H (2005) Protein Transduction Technology.
J Mol Med 83, 24-28.

Sunagawa M, Yamakawa M, Shimabukuro M, Higa N, Takasu N, Kosugi T (2005) Electrophysiologic characteristics of atrial myocytes in levo-thyroxine-treated rats.
Thyroid 15:3-11.

Yamakawa M, Sunagawa M, Shimabukuro M, Higa N, Takasu N, Kosugi T (2005) Effect of sodium channel blocker, pilsicainide hydrochloride, on net inward current of atrial myocytes in thyroid hormone toxicosis rats.
Thyroid 15:653-659.

#Matsushita M, #Noguchi H, Lu YF, Tomizawa K, Michiue H, Li ST, Hirose K, Bonner-Weir S, Matsui H (2004) Photo-acceleration of protein release from endosome in the protein transduction system.
FEBS Letters 572, 221-226. #equaly contributed

Li ST, Matsushita M, Moriwaki A, Saheki Y, Lu YF, Tomizawa K, Wu HY, Terada H, Matsui H (2004) Human Immunodeficiency Virus Type 1 Tat Potentiates Extrasynaptic N-methyl-D-Aspartate Receptor-Mediated Calcium Influx and Attenuates Spatial Learning.
Annals Neurology 55: 362-371.

Noguchi H, Matsushita M, Okitsu T, Moriwaki A, Tomizawa K, Kang S, Li ST, Kobayashi N, Tanaka K, Tanaka N, Matsui H (2004) A novel cell-permeable peptide allows successful allogeneic islet transplantation in mice.
Nature Medicine 10: 305-309.

Wu HY, Tomizawa K, Oda Y, Wei FY, Lu YF, Matsushita M, Li ST, Moriwaki A, Matsui H (2004) Critical role of calpain-mediated cleavage of calcineurinin excitotoxic neurodegeneration.
J Biol Chem 279: 4929-4940.

Sunagawa M, Shimada S, Zhang Z, Oonishi A, Nakamura M, Kosugi T (2004) Plasma insulin concentration was increased by long-term ingestion of guava juice in spontaneous non-insulin-dependent diabetes mellitus (NIDDM) rats.
J Health Sci 50: 674-678.